Genetic variant
rs55705857 a variant in the CCDC26 gene
rs55705857 is a single-letter difference in the CCDC26 gene, on chromosome 8. ClinVar, the public archive of variant interpretations, lists it as risk factor: linked to a somewhat higher chance of a condition, not a cause on its own. It has been reported in connection with Glioma susceptibility 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs55705857 is the catalogue number of one of them, in the CCDC26 gene. Which letters you carry there — one copy from each parent — is your genotype.
CCDC26 (CCDC26 long non-coding RNA): Implicated in brain cancer and high grade glioma. [provided by Alliance of Genome Resources, Jul 2025]
Gene description from NCBI Gene
rs55705857 is a SNP located in a relatively gene-poor area of chromosomal region 8q24.21, near other...
From SNPedia
Why might it matter?
ClinVar records this variant as risk factor, meaning linked to a somewhat higher chance of a condition, not a cause on its own. A classification describes the variant, not you: what it means for one person depends on their genotype, their family history and often on other genes and circumstances.
Conditions it has been reported with
- Glioma susceptibility 7
Listed in ClinVar submissions for this variant. Being listed is a report of an association, not a statement that the variant causes the condition in any given person.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs55705857, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs55705857
- Gene
- CCDC26
- Position
- chr8:129633446
- ClinVar classification
- risk factor
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Non-glioblastoma glioma | G | OR 3.39 | 7E-149 | PubMed |
| Glioma | G | OR 1.99 | 1E-78 | PubMed |
| Non-glioblastoma glioma | G | OR 4.71 | 2E-65 | PubMed |
| Non-glioblastoma glioma | G | OR 3.6 | 1E-62 | PubMed |
| Vertex-wise sulcal depth | G | OR 14.78 | 2E-49 | PubMed |
| Glioma | G | OR 2.45 | 1E-39 | PubMed |
| Glioma | G | OR 2.19 | 6E-37 | PubMed |
| Adult diffuse glioma (IDH mutation) | — | OR 11.27 | 2E-29 | PubMed |
| IDP dMRI TBSS ICVF Inferior cerebellar peduncle L | G | OR 0.23 | 5E-26 | PubMed |
| Adult diffuse glioma (IDH mutation, 1p/19q codeletion) | — | OR 10.51 | 8E-26 | PubMed |
| Brain morphology (MOSTest) | — | — | 1E-24 | PubMed |
| Adult diffuse triple positive glioma (IDH and TERT mutations, 1p19q codeletion) | — | OR 9.95 | 3E-23 | PubMed |
| Lymphocyte-to-monocyte ratio | A | — | 1E-22 | PubMed |
| IDP dMRI TBSS ICVF Retrolenticular part of internal capsule L | G | OR 0.19 | 1E-18 | PubMed |
| Whole brain restricted isotropic diffusion (multivariate analysis) | — | — | 7E-18 | PubMed |
| IDP dMRI TBSS ICVF Middle cerebellar peduncle | G | OR 0.18 | 1E-17 | PubMed |
| IDP dMRI TBSS ICVF Retrolenticular part of internal capsule R | G | OR 0.18 | 2E-17 | PubMed |
| Adult diffuse glioma (IDH mutation, 1p/19q non-codeleted) | — | OR 8.23 | 2E-16 | PubMed |
| IDP dMRI TBSS ICVF Sagittal stratum L | G | OR 0.18 | 5E-16 | PubMed |
| IDP dMRI ProbtrackX ICVF ar l | G | OR 0.17 | 5E-16 | PubMed |
Sources
- dbSNP: rs55705857 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- NCBI Gene: CCDC26
- Ensembl: CCDC26
- GWAS Catalog — association studies