Genetic variant
rs543874
rs543874 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs543874 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Recapitulation of genome-wide association studies on body mass index in the Korean population. [GWA...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs543874, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs543874
- Position
- chr1:177920345
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Weight | A | β 0.04 | 5E-165 | PubMed |
| Body size at age 10 | A | β 0.047 | 6E-163 | PubMed |
| Body mass index | G | β 0.043 | 7E-152 | PubMed |
| Body mass index | A | β 0.048 | 3E-125 | PubMed |
| Body mass index | A | β 0.048 | 3E-125 | PubMed |
| Body mass index | A | β 0.048 | 3E-125 | PubMed |
| Body mass index (MTAG) | A | β 0.046 | 9E-125 | PubMed |
| Childhood body mass index | A | β 0.059 | 2E-115 | PubMed |
| Body mass index | A | β 0.047 | 5E-105 | PubMed |
| Weight | G | β 0.041 | 2E-91 | PubMed |
| Weight (UKB data field 21002) | G | β 0.038 | 2E-80 | PubMed |
| Metabolic syndrome | — | β 0.032 | 1E-72 | PubMed |
| Body mass index (BMI, mean, inv-normal transformed) | A | β 0.063 | 2E-70 | PubMed |
| Hip circumference (UKB data field 49) | G | β 0.041 | 3E-68 | PubMed |
| Whole body water mass (UKB data field 23102) | G | β 0.023 | 2E-62 | PubMed |
| Body mass index | G | β 0.048 | 7E-62 | PubMed |
| Trunk fat mass (UKB data field 23128) | G | β 0.037 | 7E-59 | PubMed |
| Arm fat percentage right (UKB data field 23119) | G | β 0.028 | 3E-58 | PubMed |
| Weight (minimum, inv-normal transformed) | A | β 0.054 | 8E-58 | PubMed |
| Weight (maximum, inv-normal transformed) | A | β 0.061 | 1E-57 | PubMed |
Sources
- dbSNP: rs543874 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies