Genetic variant
rs541041
rs541041 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs541041 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs541041, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs541041
- Position
- chr2:21072103
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglycerides in LDL | A | β 0.07 | 2E-180 | PubMed |
| Low density lipoprotein cholesterol levels | G | OR 0.14 | 1E-146 | PubMed |
| Total cholesterol levels | G | OR 0.13 | 3E-133 | PubMed |
| Docosahexaenoic acid levels | A | β 0.06 | 2E-114 | PubMed |
| Polyunsaturated fatty acid levels | G | — | 7E-106 | PubMed |
| Polyunsaturated fatty acid levels | A | β 0.06 | 1E-102 | PubMed |
| Omega-3 fatty acids levels | A | β 0.05 | 9E-92 | PubMed |
| Phosphatidylcholine levels | A | β 0.05 | 3E-91 | PubMed |
| Total cholines levels | A | β 0.05 | 2E-90 | PubMed |
| Omega-6 fatty acids levels | A | β 0.05 | 2E-87 | PubMed |
| Free cholesterol in small HDL | A | β 0.05 | 6E-79 | PubMed |
| Phosphoglycerides levels | A | β 0.05 | 4E-78 | PubMed |
| Polyunsaturated fatty acid levels | G | — | 5E-53 | PubMed |
| Cholesteryl Esters in very large HDL | A | β 0.059 | 1E-52 | PubMed |
| Low-density lipoprotein levels (MTAG) | A | β 0.027 | 4E-50 | PubMed |
| Cholesterol in very large HDL | A | β 0.058 | 4E-50 | PubMed |
| Omega-6 fatty acid levels | G | — | 2E-48 | PubMed |
| Total cholesterol levels (MTAG) | A | β 0.051 | 1E-46 | PubMed |
| Omega-6 fatty acids to omega-3 fatty acids ratio | A | β 0.04 | 4E-46 | PubMed |
| LDL x low social support interaction (2df test) | A | OR 0.18 | 3E-44 | PubMed |
Sources
- dbSNP: rs541041 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies