RS4988321 LRP5
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What This Variant Does
"rs4988321 is a SNP in the LRP5 gene that is also known as Val667Met or V667M
Associated Conditions
Osteoporosis with pseudoglioma
8 conditions
Osteogenesis imperfecta
Retinal dystrophy
6 conditions
Disorder of bone
Osteoporosis with pseudoglioma
8 conditions
Osteogenesis imperfecta
Retinal dystrophy
6 conditions
Disorder of bone
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Heel bone mineral density | — | β: 0.088 | 2E-87 | PubMed |
| Heel bone mineral density | G | β: 0.056 | 2E-35 | PubMed |
| Bone density (confirmatory factor analysis Factor 19) | — | — | 3E-25 | PubMed |
| DXA-Bone mineral density (pelvis) (UKB data field 23232) | A | OR: 0.17 | 1E-20 | PubMed |
| DXA-Bone mineral density (head) (UKB data field 23226) | A | OR: 0.17 | 3E-20 | PubMed |
| DXA-Bone mineral density (total body) (UKB data field 23236) | A | OR: 0.17 | 5E-20 | PubMed |
| DXA-Bone mineral density (trunk) (UKB data field 23241) | A | OR: 0.17 | 2E-19 | PubMed |
| DXA-Bone mineral density (spine) (UKB data field 23234) | A | OR: 0.17 | 1E-18 | PubMed |
| DXA-Bone mineral density (lumbar spine) | A | OR: 0.17 | 2E-18 | PubMed |
| Fracture of forearm | A | OR: 1.12 | 3E-17 | PubMed |
| Osteoporosis NOS (PheCode 743.11) | G | OR: 0.17 | 3E-15 | PubMed |
| Heel bone mineral density | G | β: 0.076 | 7E-15 | PubMed |
| Forced expiratory volume (baseline) | G | β: 0.03 | 8E-15 | PubMed |
| Osteoporosis (PheCode 743.1) | G | OR: 0.16 | 9E-15 | PubMed |
| Osteoporosis NOS (PheCode 743.11) | G | OR: 0.17 | 5E-14 | PubMed |
| Osteoporosis (PheCode 743.1) | G | OR: 0.16 | 2E-13 | PubMed |
| Lung function (FEV1) | A | OR: 6.38 | 2E-10 | PubMed |
| Hip index | A | β: 0.042 | 2E-10 | PubMed |
| DXA-Bone mineral density (legs) (UKB data field 23231) | A | OR: 0.12 | 3E-10 | PubMed |
| DXA-Bone mineral density (arms) (UKB data field 23225) | A | OR: 0.11 | 1E-9 | PubMed |
Other Variants in LRP5