RS4939827 SMAD7
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What This Variant Does
"rs4939827 is one of 3 SNPs in the SMAD7 gene associated with risk for colorectal cancer, based on a ...
Associated Conditions
Colorectal cancer
susceptibility to
3
Colorectal cancer
susceptibility to
3
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Colorectal cancer | T | OR: 1.14 | 3E-30 | PubMed |
| Colorectal cancer | T | OR: 1.2 | 8E-28 | PubMed |
| Colon polyps | T | β: 0.062 | 2E-27 | PubMed |
| Colorectal polyp (UKB data field 20002_1460) | — | OR: 0.91 | 1E-20 | PubMed |
| mean corpuscular hemoglobin (MCH, mean, inv-norm transformed) | T | β: 0.023 | 3E-16 | PubMed |
| Colorectal cancer | T | OR: 1.13 | 1E-15 | PubMed |
| Colorectal cancer | T | OR: 1.13 | 2E-15 | PubMed |
| Colorectal cancer | T | OR: 1.13 | 5E-15 | PubMed |
| mean corpuscular hemoglobin (MCH, maximum, inv-norm transformed) | T | β: 0.021 | 3E-14 | PubMed |
| Mean corpuscular hemoglobin | C | β: 0.015 | 6E-14 | PubMed |
| mean corpuscular hemoglobin (MCH, minimum, inv-norm transformed) | T | β: 0.02 | 4E-13 | PubMed |
| Mean corpuscular volume | C | β: 0.016 | 9E-13 | PubMed |
| Colorectal cancer | T | OR: 1.16 | 1E-12 | PubMed |
| Mean corpuscular haemoglobin (UKB data field 30050) | C | β: 0.013 | 1E-12 | PubMed |
| Mean corpuscular hemoglobin | C | β: 0.015 | 1E-11 | PubMed |
| Mean corpuscular hemoglobin | — | — | 8E-11 | PubMed |
| Colorectal cancer x BMI interaction (2df) | — | — | 2E-10 | PubMed |
| Colorectal cancer | — | OR: 1.12 | 2E-10 | PubMed |
| Cancer (pleiotropy) | T | OR: 1.15 | 3E-10 | PubMed |
| Colorectal cancer | T | OR: 1.12 | 2E-8 | PubMed |