Genetic variant
rs4846914
rs4846914 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4846914 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
The G allele of rs4846914 is associated with higher risk of hypertriglyceridemia. ] [GWAS:HDL chole...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4846914, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4846914
- Position
- chr1:230159944
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| HS3ST3B1 protein levels | A | OR 0.13 | 2E-116 | PubMed |
| Triglycerides in small VLDL | A | β 0.04 | 4E-93 | PubMed |
| HDL cholesterol | A | β 0.041 | 4E-48 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | G | — | 1E-47 | PubMed |
| Phospholipids to Total Lipids in IDL percentage | A | β 0.03 | 3E-45 | PubMed |
| HDL cholesterol levels | A | β 0.048 | 2E-44 | PubMed |
| HDL cholesterol | G | β 0.048 | 4E-41 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | G | — | 2E-37 | PubMed |
| Platelet count (UKB data field 30080) | A | β 0.022 | 4E-36 | PubMed |
| High density lipoprotein cholesterol levels | G | β 0.041 | 3E-31 | PubMed |
| Triglycerides | G | β 0.04 | 7E-31 | PubMed |
| Triglyceride levels | A | β 0.04 | 8E-31 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | G | — | 1E-27 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | G | — | 6E-25 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | G | — | 2E-24 | PubMed |
| Platelet crit (UKB data field 30090) | A | β 0.018 | 3E-24 | PubMed |
| CSF1 protein levels | A | β 0.054 | 2E-21 | PubMed |
| HDL cholesterol | G | OR 0.61 | 4E-21 | PubMed |
| Triglycerides in very large HDL | A | β 0.02 | 2E-20 | PubMed |
| Triglycerides | G | β 0.036 | 3E-20 | PubMed |
Sources
- dbSNP: rs4846914 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies