Genetic variant

rs4841132

rs4841132 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4841132 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4841132, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs4841132
Position
chr8:9326086

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
High density lipoprotein cholesterol levels — — 2E-390 PubMed
Total cholesterol levels — — 9E-277 PubMed
high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) A OR 0.14 2E-169 PubMed
high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) A OR 0.13 5E-165 PubMed
Low density lipoprotein cholesterol levels — — 1E-157 PubMed
high density lipoprotein cholesterol (HDLC, minimm, inv-norm transformed) A OR 0.12 7E-147 PubMed
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) G — 8E-106 PubMed
HDL cholesterol A β 0.095 1E-105 PubMed
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) G — 7E-79 PubMed
Glycoprotein acetyls levels G β 0.06 2E-74 PubMed
HDL cholesterol levels in current drinkers G β 0.028 4E-74 PubMed
Non-HDL cholesterol levels A β 0.055 6E-64 PubMed
HDL cholesterol x physical activity interaction (2df test) A — 2E-63 PubMed
Alanine transaminase (ALT, mean, inv-norm transformed) A β 0.075 4E-62 PubMed
total cholesterol (mean, inv-norm transformed) A β 0.068 4E-60 PubMed
Omega-6 fatty acid levels A — 9E-59 PubMed
Alanine transaminase (ALT, mean, inv-norm transformed) A β 0.062 5E-56 PubMed
Cholesterol levels in small HDL A OR 0.11 3E-54 PubMed
total cholesterol (minimum, inv-norm transformed) A β 0.062 4E-54 PubMed
Alanine transaminase (ALT, maximum, inv-norm transformed) A β 0.06 5E-54 PubMed

Sources