Genetic variant
rs4835265
rs4835265 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4835265 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4835265, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4835265
- Position
- chr4:145900258
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Gamma glutamyl transpeptidase | A | β 0.089 | 4E-317 | PubMed |
| Liver enzyme levels (gamma-glutamyl transferase) | C | β 0.028 | 1E-300 | PubMed |
| Gamma glutamyl transferase levels | A | OR 0.11 | 3E-265 | PubMed |
| Gamma glutamyl transferase levels | A | β 0.08 | 6E-145 | PubMed |
| Gamma glutamyl transferase levels | — | — | 1E-136 | PubMed |
| Gamma glutamyl transferase levels | A | β 0.073 | 6E-134 | PubMed |
| Alanine aminotransferase levels | A | β 0.039 | 3E-124 | PubMed |
| Liver enzyme levels (gamma-glutamyl transferase) | — | — | 1E-106 | PubMed |
| Alanine aminotransferase levels | A | β 0.01 | 9E-85 | PubMed |
| Alanine aminotransferase levels | — | β 0.01 | 2E-76 | PubMed |
| Liver enzyme levels (alanine transaminase) | C | β 0.01 | 8E-76 | PubMed |
| Aspartate aminotransferase levels | A | β 0.031 | 3E-74 | PubMed |
| Alanine aminotransferase levels | A | β 0.057 | 3E-67 | PubMed |
| Alanine aminotransferase levels | A | β 0.04 | 3E-64 | PubMed |
| MME protein levels | A | β 0.045 | 5E-63 | PubMed |
| Alanine aminotransferase levels | A | OR 16.7 | 2E-62 | PubMed |
| Gamma glutamyl transferase levels | — | β 0.072 | 3E-61 | PubMed |
| Gamma glutamyl transferase levels | — | β 0.071 | 1E-58 | PubMed |
| NT5E protein levels | A | β 0.088 | 4E-56 | PubMed |
| SDHB protein levels | A | OR 0.13 | 1E-54 | PubMed |
Sources
- dbSNP: rs4835265 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies