Genetic variant

rs4810479

rs4810479 is a single-letter difference in human DNA, on chromosome 20. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4810479 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4810479, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs4810479
Position
chr20:45916409

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Free Cholesterol to Total Lipids in Medium VLDL percentage T β 0.076 1E-125 PubMed
Cholesteryl Esters to Total Lipids in Small HDL percentage T β 0.05 2E-124 PubMed
Triglycerides to Total Lipids in Medium VLDL percentage T β 0.071 8E-111 PubMed
Triglycerides in very large HDL T β 0.05 2E-102 PubMed
Triglycerides in large HDL T β 0.03 6E-60 PubMed
Sphingomyelins levels T β 0.05 1E-54 PubMed
Metabolite levels — — 2E-42 PubMed
Free Cholesterol to Total Lipids in Medium VLDL percentage T β 0.046 5E-40 PubMed
Triglycerides to Total Lipids in Medium VLDL percentage T β 0.045 5E-39 PubMed
Phospholipids to Total Lipids in Medium HDL percentage T β 0.038 8E-34 PubMed
HDL cholesterol x physical activity interaction (2df test) T — 8E-34 PubMed
Cholesteryl esters to total lipids ratio in very large VLDL T β 0.057 5E-33 PubMed
Total cholesterol to total lipids ratio in very large VLDL T β 0.057 1E-32 PubMed
Phospholipids to total lipids ratio in medium HDL T β 0.051 6E-30 PubMed
Blood protein levels in cardiovascular risk T OR 0.18 3E-25 PubMed
High density lipoprotein cholesterol levels C β 0.039 8E-24 PubMed
Cholesteryl esters to total lipids ratio in large VLDL T β 0.045 7E-23 PubMed
Triglycerides to total lipids ratio in very large VLDL T β 0.048 2E-22 PubMed
Serum alkaline phosphatase levels T β 0.02 1E-18 PubMed
TACSTD2 protein levels T β 0.039 4E-17 PubMed

Sources