Genetic variant
rs4702
rs4702 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4702 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4702, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4702
- Position
- chr15:90883330
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Vertex-wise sulcal depth | G | OR 18.31 | 7E-75 | PubMed |
| Height | G | β 0.01 | 9E-57 | PubMed |
| Insomnia | A | β 0.011 | 3E-31 | PubMed |
| Schizophrenia | — | — | 6E-26 | PubMed |
| Schizophrenia | G | OR 1.08 | 6E-25 | PubMed |
| Externalizing behaviour (multivariate analysis) | G | β 0.012 | 1E-23 | PubMed |
| Schizophrenia or ER positive breast cancer (pleiotropy) | G | — | 1E-22 | PubMed |
| Schizophrenia or breast cancer (pleiotropy) | G | — | 2E-22 | PubMed |
| GDF2 protein levels | A | β 0.044 | 7E-21 | PubMed |
| Major depressive disorder | — | β 0.024 | 3E-19 | PubMed |
| Vertex-wise cortical thickness | G | OR 8.89 | 6E-19 | PubMed |
| Cortical thickness | G | — | 1E-17 | PubMed |
| Insomnia | A | β 0.01 | 3E-17 | PubMed |
| HRC protein levels | A | β 0.048 | 3E-17 | PubMed |
| Number of sexual partners | A | β 0.02 | 6E-17 | PubMed |
| Whole brain restricted directional diffusion (multivariate analysis) | — | — | 7E-17 | PubMed |
| Age at first sexual intercourse | G | β 0.017 | 1E-16 | PubMed |
| Insomnia | G | OR 1.05 | 7E-16 | PubMed |
| BMP10 protein levels | A | β 0.041 | 1E-15 | PubMed |
| Schizophrenia | — | OR 1.08 | 2E-15 | PubMed |
Sources
- dbSNP: rs4702 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies