Genetic variant
rs4575545
rs4575545 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4575545 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4575545, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4575545
- Position
- chr16:79721549
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Liver enzyme levels (alkaline phosphatase) | G | β 0.006 | 6E-114 | PubMed |
| Alkaline phosphatase (UKB data field 30610) | A | β 0.041 | 1E-103 | PubMed |
| Serum alkaline phosphatase levels | A | β 0.044 | 4E-89 | PubMed |
| Serum alkaline phosphatase levels | A | OR 18.9 | 8E-80 | PubMed |
| TTR protein levels | A | β 0.089 | 3E-53 | PubMed |
| Serum urate levels | A | β 0.038 | 4E-51 | PubMed |
| Urate levels (UKB data field 30880) | A | β 0.024 | 8E-44 | PubMed |
| Serum uric acid levels | A | β 0.027 | 2E-43 | PubMed |
| Urate levels | A | β 0.025 | 9E-37 | PubMed |
| Platelet count | A | — | 4E-32 | PubMed |
| Platelet count | A | β 0.02 | 8E-30 | PubMed |
| Platelet count | A | β 0.02 | 5E-21 | PubMed |
| CPM protein levels | A | β 0.047 | 2E-18 | PubMed |
| FCAMR protein levels | A | β 0.043 | 9E-14 | PubMed |
| Serum 25-Hydroxyvitamin D levels (conditioned on BMI) | G | β 0.016 | 3E-13 | PubMed |
| IGF 1 (UKB data field 30770) | A | β 0.014 | 9E-13 | PubMed |
| Gout (PheCode 274.1) | G | β 0.057 | 1E-12 | PubMed |
| Gout and other crystal arthrop (PheCode 274) | G | β 0.057 | 1E-12 | PubMed |
| Serum 25-Hydroxyvitamin D levels | — | β 0.015 | 7E-12 | PubMed |
| Gout (PheCode 274.1) | G | β 0.065 | 8E-12 | PubMed |
Sources
- dbSNP: rs4575545 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies