Genetic variant
rs45446698
rs45446698 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs45446698 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
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From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs45446698, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs45446698
- Position
- chr7:99735325
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Androsterone sulfate levels | T | OR 1.75 | 2E-1107 | PubMed |
| Epiandrosterone sulfate levels | T | OR 1.58 | 6E-898 | PubMed |
| Total testosterone levels | T | OR 0.37 | 2E-635 | PubMed |
| 16a-hydroxy DHEA 3-sulfate levels | T | OR 1.22 | 9E-539 | PubMed |
| 5alpha-androstan-3alpha,17beta-diol monosulfate (1) levels | T | OR 1.51 | 3E-456 | PubMed |
| Androsterone sulfate levels | G | OR 1.41 | 1E-359 | PubMed |
| 4-androsten-3alpha,17alpha-diol monosulfate (3) levels | T | OR 1 | 1E-353 | PubMed |
| 5alpha-androstan-3beta,17beta-diol disulfate levels | T | OR 0.97 | 3E-328 | PubMed |
| X-21668 levels | T | OR 0.98 | 9E-322 | PubMed |
| Total testosterone levels | T | OR 0.12 | 2E-315 | PubMed |
| Androsterone sulfate levels | G | OR 1.42 | 1E-308 | PubMed |
| Testosterone levels | G | OR 0.32 | 6E-293 | PubMed |
| Testosterone levels | — | OR 36.48 | 3E-291 | PubMed |
| Andro steroid monosulfate (1) levels | T | OR 0.92 | 5E-290 | PubMed |
| Total testosterone levels | — | OR 0.32 | 1E-289 | PubMed |
| Epiandrosterone sulfate levels | G | OR 1.25 | 4E-286 | PubMed |
| Epiandrosterone sulfate levels | G | OR 1.36 | 8E-285 | PubMed |
| Tauro-beta-muricholate levels | T | OR 0.94 | 3E-249 | PubMed |
| 5alpha-androstan-3alpha,17beta-diol monosulfate (1) levels | G | OR 1.41 | 5E-243 | PubMed |
| 16a-hydroxy DHEA 3-sulfate levels | G | OR 1.18 | 6E-243 | PubMed |
Sources
- dbSNP: rs45446698 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies