Genetic variant
rs445
rs445 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs445 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs445, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs445
- Position
- chr7:92779056
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| White blood cell count | T | β 0.069 | 5E-371 | PubMed |
| White blood cell count | T | — | 3E-310 | PubMed |
| Neutrophil count | T | — | 1E-239 | PubMed |
| Monocyte count | T | — | 2E-219 | PubMed |
| white blood cell count (WBC, mean, inv-norm transformed) | C | OR 0.14 | 2E-211 | PubMed |
| White blood cell count | T | β 0.095 | 2E-205 | PubMed |
| White blood cell count | T | β 0.082 | 9E-201 | PubMed |
| monocyte (absolute count, mean, inv-norm transformed) | C | OR 0.16 | 1E-198 | PubMed |
| Monocyte count | T | β 0.094 | 4E-196 | PubMed |
| Neutrophil count | T | OR 0.11 | 3E-182 | PubMed |
| Neutrophil count | T | β 0.091 | 1E-175 | PubMed |
| White blood cell count | T | OR 0.1 | 1E-160 | PubMed |
| Neutrophil count | T | β 0.085 | 7E-159 | PubMed |
| white blood cell count (WBC, minimum, inv-norm transformed) | C | OR 0.12 | 6E-154 | PubMed |
| White blood cell count | — | — | 6E-148 | PubMed |
| white blood cell count (WBC, mean, inv-norm transformed) | C | OR 0.11 | 3E-145 | PubMed |
| Eosinophil side scatter | T | OR 0.34 | 4E-142 | PubMed |
| Basophil count | T | β 0.097 | 1E-141 | PubMed |
| Eosinophil side fluorescence | T | OR 0.33 | 3E-139 | PubMed |
| monocyte (absolute count, maximum, inv-norm transformed) | C | OR 0.13 | 3E-137 | PubMed |
Sources
- dbSNP: rs445 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies