Genetic variant
rs4409764
rs4409764 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4409764 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Implicated in a 2015 Korean cohort for Crohn's disease. [PMID: 25489960] [GWAS:None]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4409764, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4409764
- Position
- chr10:99524480
Genome-wide association studies (13)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Inflammatory bowel disease | — | OR 0.16 | 3E-72 | PubMed |
| Inflammatory bowel disease | T | OR 1.18 | 1E-54 | PubMed |
| Crohn's disease | — | OR 0.18 | 4E-50 | PubMed |
| Crohn's disease | A | OR 1.19 | 6E-47 | PubMed |
| Ulcerative colitis | — | OR 0.15 | 3E-40 | PubMed |
| Ulcerative colitis | A | OR 1.17 | 2E-36 | PubMed |
| Inflammatory bowel disease | — | — | 2E-34 | PubMed |
| Crohn's disease | — | — | 2E-24 | PubMed |
| Ulcerative colitis | — | — | 2E-21 | PubMed |
| Crohn's disease | T | OR 1.22 | 2E-20 | PubMed |
| Inflammatory bowel disease and other gasteroenteritis and colitis (PheCode 555) | T | OR 0.1 | 1E-12 | PubMed |
| Crohn's disease | T | OR 1.32 | 8E-8 | PubMed |
| Ulcerative colitis | T | OR 1.12 | 6E-7 | PubMed |
Sources
- dbSNP: rs4409764 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies