RS440446 Unknown gene
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What This Variant Does
"rs440446 is a SNP in an intron of the apolipoprotein E APOE gene
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Alzheimer's disease (onset between ages 58 and 79) | G | OR: 1.64 | 9E-59 | PubMed |
| Alzheimer's disease | C | OR: 0.65 | 7E-25 | PubMed |
| Total fatty acid levels | C | — | 6E-24 | PubMed |
| Baseline memory | — | β: 0.08 | 3E-20 | PubMed |
| Baseline memory | — | β: 0.08 | 5E-19 | PubMed |
| Polyunsaturated fatty acid levels | C | — | 2E-18 | PubMed |
| Memory decline | — | β: 0.009 | 4E-17 | PubMed |
| Omega-6 fatty acid levels | C | — | 3E-16 | PubMed |
| Memory decline | — | β: 0.008 | 6E-16 | PubMed |
| Memory decline | — | β: 0.009 | 4E-15 | PubMed |
| Memory decline | — | β: 0.009 | 2E-14 | PubMed |
| Eosinophil count | — | — | 3E-12 | PubMed |
| Eosinophill count (UKB data field 30150) | G | β: 0.014 | 5E-12 | PubMed |
| Baseline memory | — | β: 0.067 | 6E-12 | PubMed |
| Multi-trait sex score | — | — | 1E-11 | PubMed |
| Baseline memory | — | β: 0.065 | 2E-11 | PubMed |
| Baseline memory in impaired cognition | — | OR: 0.11 | 1E-10 | PubMed |
| Baseline memory in impaired cognition | — | OR: 0.12 | 3E-10 | PubMed |
| Memory decline in impaired cognition | — | β: 0.015 | 1E-9 | PubMed |
| Symbol digit substitution test performance (baseline) | C | β: 0.02 | 2E-9 | PubMed |