RS4129267 Unknown gene
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What This Variant Does
"A 2012 educational article explained that in autoimmune inflammatory conditions, IL-6 promotes antib..."
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Interleukin-6 receptor subunit alpha levels (IL6R.4139.71.2) | T | OR: 1.1 | 6E-1040 | PubMed |
| IL6 protein levels | T | OR: 0.21 | 2E-311 | PubMed |
| Interleukin-6 receptor subunit alpha levels | T | OR: 1.14 | 4E-303 | PubMed |
| Blood protein levels in cardiovascular risk | T | OR: 0.81 | 2E-297 | PubMed |
| Interleukin-6 receptor subunit alpha levels | T | OR: 1.21 | 2E-265 | PubMed |
| C-reactive protein levels | C | β: 0.088 | 1E-129 | PubMed |
| Interleukin-6 receptor subunit alpha levels | T | OR: 0.84 | 4E-58 | PubMed |
| Protein quantitative trait loci | — | — | 2E-57 | PubMed |
| C-reactive protein levels | C | β: 0.079 | 2E-48 | PubMed |
| Fibrinogen levels or factor VII levels or factor XI levels or tissue plasminogen activator levels (pleiotropy) | — | — | 2E-38 | PubMed |
| Fibrinogen levels or tissue plasminogen activator levels (pleiotropy) | — | — | 2E-37 | PubMed |
| Fibrinogen levels or plasminogen activator inhibitor 1 levels (pleiotropy) | — | — | 4E-37 | PubMed |
| C-reactive protein levels | — | OR: 0.11 | 1E-33 | PubMed |
| Fibrinogen | T | β: 0.011 | 6E-27 | PubMed |
| C-reactive protein levels | A | OR: 0.12 | 2E-26 | PubMed |
| mean corpuscular hemoglobin (MCH, maximum, inv-norm transformed) | C | β: 0.033 | 9E-23 | PubMed |
| C-reactive protein levels | T | β: 0.082 | 8E-22 | PubMed |
| Atopic dermatitis | — | β: 0.069 | 4E-20 | PubMed |
| mean corpuscular volume (MCV, maximum, inv-norm transformed) | C | β: 0.029 | 2E-18 | PubMed |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) | — | — | 9E-18 | PubMed |