Genetic variant
rs4072037
rs4072037 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4072037 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
cancer-associated Genome-wide survey of allele-specific splicing in humans. MUC1 and estrogen recept...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4072037, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4072037
- Position
- chr1:155192276
Genome-wide association studies (13)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Magnesium levels | C | β 0.01 | 2E-36 | PubMed |
| Serum uric acid levels | T | β 0.048 | 7E-20 | PubMed |
| Serum cancer antigen 15.3 levels | — | OR 1.1 | 1E-18 | PubMed |
| Non-cardia gastric cancer | T | OR 1.35 | 6E-17 | PubMed |
| Serum uric acid levels | — | β 0.045 | 9E-16 | PubMed |
| Magnesium levels | C | β 0.012 | 9E-12 | PubMed |
| Diastolic blood pressure | T | OR 0.32 | 9E-10 | PubMed |
| Gastric cancer | — | OR 1.27 | 2E-9 | PubMed |
| Gastric cancer | A | OR 1.32 | 7E-8 | PubMed |
| Esophageal cancer and gastric cancer | A | OR 1.33 | 4E-7 | PubMed |
| Parkinson disease | — | OR 1.07 | 1E-6 | PubMed |
| Urinary albumin-to-creatinine ratio | T | β 0.029 | 3E-6 | PubMed |
| Urinary albumin-to-creatinine ratio in non-diabetics | T | β 0.028 | 9E-6 | PubMed |
Sources
- dbSNP: rs4072037 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies