Genetic variant
rs3865444
rs3865444 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs3865444 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
The less common allele for this SNP, rs3865444(T), is associated with a slight decrease in risk for ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs3865444, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs3865444
- Position
- chr19:51224706
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| CD33 on CD33dim HLA DR+ CD11b+ | A | OR 1.14 | 2E-191 | PubMed |
| CD33 on CD14+ monocyte | A | OR 1.14 | 1E-190 | PubMed |
| CD33 on CD33+ HLA DR+ CD14- | A | OR 1.22 | 9E-189 | PubMed |
| CD33 on CD33+ HLA DR+ | A | OR 1.22 | 3E-187 | PubMed |
| CD33 on CD33+ HLA DR+ CD14dim | A | OR 1.21 | 8E-184 | PubMed |
| CD33 on CD33dim HLA DR+ CD11b- | A | OR 1.12 | 2E-183 | PubMed |
| CD33 on Monocytic Myeloid-Derived Suppressor Cells | A | OR 1.15 | 2E-153 | PubMed |
| CD33 on CD33dim HLA DR- | A | OR 1.14 | 3E-145 | PubMed |
| CD33 on CD66b++ myeloid cell | A | OR 0.95 | 2E-108 | PubMed |
| Basophil %CD33dim HLA DR- CD66b- | A | OR 0.52 | 1E-40 | PubMed |
| Platelet count | A | β 0.025 | 1E-37 | PubMed |
| Platelet count | A | — | 2E-37 | PubMed |
| Basophil Absolute Count | A | OR 0.49 | 8E-35 | PubMed |
| Plateletcrit | A | β 0.026 | 1E-26 | PubMed |
| white blood cell count (WBC, mean, inv-norm transformed) | C | β 0.037 | 3E-26 | PubMed |
| Myeloid cell surface antigen CD33 level in Chronic kidney disease with hypertension and no diabetes (3166_92) | A | OR 1.09 | 6E-26 | PubMed |
| Lymphocyte count | A | β 0.024 | 1E-24 | PubMed |
| Lymphocyte count (UKB data field 30120) | A | β 0.021 | 5E-24 | PubMed |
| Platelet count | A | β 0.024 | 2E-23 | PubMed |
| red cell diameter width (RDW, mean, inv-norm transformed) | C | β 0.028 | 4E-23 | PubMed |
Sources
- dbSNP: rs3865444 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies