Genetic variant
rs3827760
rs3827760 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs3827760 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs3827760, also known as 1540T/C, 370A, V370A or Val370Ala, is a SNP in the ectodysplasin A receptor...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs3827760, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs3827760
- Position
- chr2:108897145
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Scalp hair shape | — | — | 3E-119 | PubMed |
| Curly vs straight hair | A | OR 2.92 | 1E-16 | PubMed |
| Male-pattern baldness | G | OR 0.19 | 4E-16 | PubMed |
| Straight vs curly hair | G | — | 5E-16 | PubMed |
| Monobrow | — | OR 0.17 | 2E-15 | PubMed |
| Hair/balding pattern: Pattern 1 (UKB data field 2395_1) | G | OR 0.41 | 1E-14 | PubMed |
| Balding type 1 | — | — | 5E-14 | PubMed |
| Facial appearance | — | — | 2E-13 | PubMed |
| Lobe size | G | OR 0.12 | 1E-12 | PubMed |
| Helix rolling | G | OR 0.1 | 1E-12 | PubMed |
| Ear morphology | G | — | 1E-11 | PubMed |
| Ear protrusion | G | OR 0.11 | 1E-10 | PubMed |
| lower facial morphology traits (quantitative measurement) | G | β 0.008 | 4E-10 | PubMed |
| Lobe attachment (rater scored) | — | — | 7E-10 | PubMed |
| Thick vs thin eyebrows | G | OR 1.41 | 2E-9 | PubMed |
| Lobe attachment | G | β 0.066 | 2E-9 | PubMed |
| Male-pattern baldness | — | OR 2.24 | 1E-8 | PubMed |
| Monobrow thickness | — | — | 1E-7 | PubMed |
| Eyebrow thickness | — | — | 1E-7 | PubMed |
| Urinary albumin-to-creatinine ratio | G | β 0.097 | 2E-7 | PubMed |
Sources
- dbSNP: rs3827760 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies