RS3732359 Unknown gene
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What This Variant Does
"Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism"
GWAS Studies (15)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Total cholesterol levels | A | β: 0.021 | 9E-35 | PubMed |
| Total cholesterol levels | A | β: 0.02 | 6E-26 | PubMed |
| Low-density lipoprotein levels | A | β: 0.017 | 9E-22 | PubMed |
| Low-density lipoprotein levels (MTAG) | A | β: 0.014 | 2E-17 | PubMed |
| Low density lipoprotein cholesterol levels | — | — | 6E-17 | PubMed |
| Low density lipoprotein cholesterol levels | A | β: 0.015 | 6E-15 | PubMed |
| Weight | A | β: 0.014 | 5E-14 | PubMed |
| Body mass index | A | β: 0.012 | 2E-13 | PubMed |
| Non-HDL cholesterol levels | — | — | 8E-13 | PubMed |
| LDL cholesterol levels | G | β: 0.017 | 5E-12 | PubMed |
| Body mass index | A | β: 0.014 | 1E-11 | PubMed |
| Non-HDL cholesterol levels | G | β: 0.015 | 2E-11 | PubMed |
| Omega-6 fatty acids levels | A | β: 0.02 | 1E-10 | PubMed |
| Total lipid levels in lipoprotein particles | A | β: 0.02 | 1E-10 | PubMed |
| Body mass index | A | β: 0.016 | 2E-8 | PubMed |