Genetic variant
rs362307
rs362307 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs362307 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease pati...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs362307, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs362307
- Position
- chr4:3240118
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Drinks per week | T | β 0.02 | 1E-32 | PubMed |
| Educational attainment | T | β 0.023 | 4E-30 | PubMed |
| Drinks per week | T | β 0.02 | 1E-29 | PubMed |
| Educational attainment (years of education) | T | β 0.023 | 2E-17 | PubMed |
| Physical function (baseline) | C | β 0.015 | 4E-14 | PubMed |
| Automobile speeding propensity | T | β 0.032 | 6E-14 | PubMed |
| CAMSIS occupational score (MTAG) | — | β 0.023 | 1E-12 | PubMed |
| Type 2 diabetes | T | — | 2E-12 | PubMed |
| SIOPS occupational score (MTAG) | — | β 0.021 | 3E-12 | PubMed |
| ISEI occupational score (MTAG) | — | β 0.021 | 6E-12 | PubMed |
| Brain morphology (MOSTest) | — | — | 1E-11 | PubMed |
| Worry too long after an embarrassing experience | T | OR 6.13 | 9E-10 | PubMed |
| Forced expiratory volume (baseline) | C | β 0.02 | 1E-9 | PubMed |
| Walking pace | C | β 0.015 | 1E-9 | PubMed |
| Type 2 diabetes | T | OR 1.08 | 1E-9 | PubMed |
| Worry/vulnerability (special factor of neuroticism) | C | β 0.008 | 1E-9 | PubMed |
| Household income (MTAG) | T | β 0.024 | 2E-9 | PubMed |
| Predicted visceral adipose tissue | T | β 0.029 | 2E-9 | PubMed |
| Income (MTAG) | — | β 0.019 | 2E-9 | PubMed |
| Hepatocyte growth factor levels | — | β 0.091 | 6E-9 | PubMed |
Sources
- dbSNP: rs362307 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies