RS35947132 PRF1
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What This Variant Does
"Macrophage activation syndrome in 13 children with systemic-onset juvenile idiopathic arthritis. [O...
Associated Conditions
Hemophagocytic lymphohistiocytosis
familial
2
susceptibility to
Familial hemophagocytic lymphohistiocytosis 2
Autoinflammatory syndrome
PRF1-related disorder
Hemophagocytic lymphohistiocytosis
familial
2
susceptibility to
Familial hemophagocytic lymphohistiocytosis 2
Autoinflammatory syndrome
PRF1-related disorder
GWAS Studies (17)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| lymphocyte (absolute count, maximum, inv-norm transformed) | G | OR: 0.1 | 7E-34 | PubMed |
| lymphocyte (absolute count, mean, inv-norm transformed) | G | β: 0.099 | 1E-32 | PubMed |
| Lymphocyte count | A | β: 0.062 | 1E-27 | PubMed |
| lymphocyte (fraction, maximum, inv-norm transformed) | G | β: 0.077 | 8E-26 | PubMed |
| lymphocyte (fraction, mean, inv-norm transformed) | G | β: 0.073 | 2E-24 | PubMed |
| lymphocyte (absolute count, maximum, inv-norm transformed) | G | β: 0.096 | 2E-23 | PubMed |
| lymphocyte (absolute count, mean, inv-norm transformed) | G | β: 0.091 | 9E-22 | PubMed |
| lymphocyte (fraction, maximum, inv-norm transformed) | G | β: 0.075 | 2E-19 | PubMed |
| lymphocyte (fraction, mean, inv-norm transformed) | G | β: 0.069 | 1E-17 | PubMed |
| lymphocyte (absolute count, minimum, inv-norm transformed) | G | β: 0.064 | 6E-16 | PubMed |
| neutrophil (fraction, minimum, inv-norm transformed) | G | β: 0.062 | 6E-15 | PubMed |
| neutrophil (fraction, mean, inv-norm transformed) | G | β: 0.06 | 3E-14 | PubMed |
| lymphocyte (absolute count, minimum, inv-norm transformed) | G | β: 0.06 | 2E-12 | PubMed |
| Neutrophil-to-lymphocyte ratio | G | — | 3E-11 | PubMed |
| neutrophil (fraction, minimum, inv-norm transformed) | G | β: 0.059 | 4E-11 | PubMed |
| Lymphocyte count | G | — | 2E-9 | PubMed |
| Lymphocyte-to-monocyte ratio | G | — | 5E-9 | PubMed |
Other Variants in PRF1