Genetic variant
rs35923643
rs35923643 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs35923643 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relation to chronic lymphocytic leukemia.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs35923643, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs35923643
- Position
- chr11:123484683
Genome-wide association studies (17)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Chronic lymphocytic leukemia | G | OR 1.63 | 4E-58 | PubMed |
| Lymphoid leukemia, chronic (PheCode 204.12) | A | OR 0.45 | 4E-44 | PubMed |
| Lymphoid leukemia, chronic (PheCode 204.12) | A | OR 0.45 | 2E-43 | PubMed |
| Lymphoid leukemia (PheCode 204.1) | A | OR 0.42 | 4E-43 | PubMed |
| Lymphoid leukemia (PheCode 204.1) | A | OR 0.42 | 2E-41 | PubMed |
| Chronic lymphocytic leukemia | G | OR 1.66 | 2E-40 | PubMed |
| CD5L protein levels | G | β 0.079 | 6E-35 | PubMed |
| ANXA1 protein levels | G | β 0.081 | 6E-27 | PubMed |
| ZNRD2 protein levels | G | β 0.074 | 4E-25 | PubMed |
| AFAP1 protein levels | G | β 0.045 | 1E-17 | PubMed |
| GART protein levels | G | β 0.065 | 8E-17 | PubMed |
| Fas apoptotic inhibitory molecule 3 levels | A | OR 0.13 | 2E-15 | PubMed |
| Lymphocyte percentage (UKB data field 30180) | G | β 0.019 | 1E-14 | PubMed |
| Malignant lymphoma (Non-Hodgkin lymphoma, multiple myeloma, or Hodgkin lymphoma) | G | OR 1.19 | 8E-13 | PubMed |
| Immunoglobulin M against phosphorylcholine (IgM anti-PC) levels | G | OR 0.19 | 4E-11 | PubMed |
| Mean platelet volume | A | β 0.015 | 3E-10 | PubMed |
| Neutrophils and lymphocytes in blood (confirmatory factor analysis Factor 35) | — | — | 4E-8 | PubMed |
Sources
- dbSNP: rs35923643 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies