RS35705950 MUC5B
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What This Variant Does
"rs35705950 is a SNP located 3 kb upstream of the start of transcription from the mucin 5B MUC5B gene...
Associated Conditions
Pulmonary fibrosis
idiopathic
susceptibility to
Interstitial lung disease 2
Susceptibility to coronavirus disease (COVID-19) severity and mortality due to low plasma levels of MUC5B
Antisynthetase syndrome
Pulmonary fibrosis
idiopathic
susceptibility to
Interstitial lung disease 2
Susceptibility to coronavirus disease (COVID-19) severity and mortality due to low plasma levels of MUC5B
Antisynthetase syndrome
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Idiopathic pulmonary fibrosis | T | OR: 5.06 | 9E-418 | PubMed |
| Other alveolar and parietoalveolar pneumonopathy (PheCode 504) | G | OR: 0.99 | 1E-323 | PubMed |
| Postinflammatory pulmonary fibrosis (PheCode 502) | G | OR: 0.87 | 1E-323 | PubMed |
| Other alveolar and parietoalveolar pneumonopathy (PheCode 504) | G | OR: 0.98 | 1E-278 | PubMed |
| Postinflammatory pulmonary fibrosis (PheCode 502) | G | OR: 0.86 | 5E-257 | PubMed |
| Idiopathic fibrosing alveolitis (PheCode 504.1) | G | OR: 1.07 | 5E-245 | PubMed |
| Idiopathic pulmonary fibrosis | T | OR: 4.84 | 1E-203 | PubMed |
| Idiopathic fibrosing alveolitis (PheCode 504.1) | G | OR: 1.06 | 2E-178 | PubMed |
| Interstitial lung disease | T | OR: 1.01 | 1E-76 | PubMed |
| Idiopathic pulmonary fibrosis | T | OR: 2.89 | 1E-66 | PubMed |
| Pulmonary fibrosis | T | OR: 1.12 | 2E-65 | PubMed |
| Idiopathic pulmonary fibrosis | T | OR: 2.43 | 2E-50 | PubMed |
| white blood cell count (WBC, mean, inv-norm transformed) | G | β: 0.061 | 3E-44 | PubMed |
| Other alveolar and parietoalveolar pneumonopathy (PheCode 504) | G | OR: 1.2 | 6E-33 | PubMed |
| Postinflammatory pulmonary fibrosis (PheCode 502) | G | OR: 1.08 | 2E-31 | PubMed |
| white blood cell count (WBC, minimum, inv-norm transformed) | G | β: 0.05 | 8E-31 | PubMed |
| Subpleural-predominant interstitial lung abnormalities | T | OR: 2.22 | 2E-29 | PubMed |
| neutrophil (absolute count, mean, inv-norm transformed) | G | β: 0.053 | 2E-29 | PubMed |
| Interstitial lung abnormalities | T | OR: 1.98 | 4E-27 | PubMed |
| neutrophil (absolute count, minimum, inv-norm transformed) | G | β: 0.051 | 2E-26 | PubMed |
Other Variants in MUC5B