Genetic variant
rs35518360
rs35518360 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs35518360 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs35518360 is a SNP that has been found to be associated with schizophrenia. Schizophrenia is a ment...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs35518360, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs35518360
- Position
- chr4:102225733
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| hematocrit (mean, inv-norm transformed) | A | β 0.044 | 2E-20 | PubMed |
| red blood cell count (RBC, mean, inv-norm transformed) | A | β 0.041 | 1E-18 | PubMed |
| Phospholipids in large HDL (UKB data field 23560) | T | β 0.069 | 2E-18 | PubMed |
| Total lipids in large HDL (UKB data field 23559) | T | β 0.068 | 6E-18 | PubMed |
| Concentration of large HDL particles (UKB data field 23558) | T | β 0.067 | 1E-17 | PubMed |
| Free cholesterol in large HDL (UKB data field 23563) | T | β 0.066 | 5E-17 | PubMed |
| Phospholipids to total lipids ratio in large VLDL | A | β 0.062 | 9E-17 | PubMed |
| Cholesterol in large HDL (UKB data field 23561) | T | β 0.065 | 1E-16 | PubMed |
| Cholesteryl esters to total lipids ratio in IDL | A | β 0.062 | 2E-16 | PubMed |
| hemoglobin (mean, inv-norm transformed) | A | β 0.043 | 9E-16 | PubMed |
| red blood cell count (RBC, mean, inv-norm transformed) | A | β 0.047 | 1E-15 | PubMed |
| Average diameter for HDL particles (UKB data field 23433) | T | β 0.062 | 4E-15 | PubMed |
| Phospholipids to total lipids in large VLDL percentage (UKB data field 23589) | T | β 0.067 | 5E-15 | PubMed |
| Physical function (baseline) | A | β 0.015 | 7E-15 | PubMed |
| Schizophrenia | T | OR 1.17 | 8E-15 | PubMed |
| Cholesterol to total lipids ratio in IDL | A | β 0.057 | 2E-14 | PubMed |
| Abnormal movement (PheCode 350) | A | β 0.072 | 4E-13 | PubMed |
| Concentration of very large HDL particles | A | β 0.065 | 6E-13 | PubMed |
| Income (MTAG) | — | β 0.024 | 1E-12 | PubMed |
| Abnormality of gait (PheCode 350.2) | A | β 0.077 | 4E-12 | PubMed |
Sources
- dbSNP: rs35518360 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies