Genetic variant
rs351855 a variant in the FGFR4 gene
rs351855 is a single-letter difference in the FGFR4 gene, on chromosome 5. ClinVar, the public archive of variant interpretations, lists it as conflicting interpretations: laboratories that have assessed it do not agree on whether it matters. It has been reported in connection with Cancer progression and tumor cell motility and FGFR4-related disorder. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs351855 is the catalogue number of one of them, in the FGFR4 gene. Which letters you carry there — one copy from each parent — is your genotype.
FGFR4 (fibroblast growth factor receptor 4): The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis.
Gene description from NCBI Gene
rs351855, a SNP in the fibroblast growth factor receptor 4 (FGFR4) gene, is also known as the Gly388...
From SNPedia
Why might it matter?
ClinVar records this variant as conflicting interpretations, meaning laboratories that have assessed it do not agree on whether it matters. A classification describes the variant, not you: what it means for one person depends on their genotype, their family history and often on other genes and circumstances.
Conditions it has been reported with
- Cancer progression and tumor cell motility
- FGFR4-related disorder
Listed in ClinVar submissions for this variant. Being listed is a report of an association, not a statement that the variant causes the condition in any given person.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs351855, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs351855
- Gene
- FGFR4
- Position
- chr5:177093242
- ClinVar classification
- Conflicting classifications of pathogenicity
Genome-wide association studies (12)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Impedance of whole body (UKB data field 23106) | A | β 0.017 | 4E-29 | PubMed |
| Impedance of arm right (UKB data field 23109) | A | β 0.012 | 8E-16 | PubMed |
| Impedance of arm left (UKB data field 23110) | A | β 0.011 | 2E-13 | PubMed |
| hemoglobin (minimum, inv-norm transformed) | G | β 0.017 | 1E-11 | PubMed |
| Hemoglobin levels | A | β 0.016 | 2E-11 | PubMed |
| Low density lipoprotein cholesterol levels | A | β 0.013 | 1E-9 | PubMed |
| Waist circumference adjusted for body mass index | A | β 0.02 | 1E-9 | PubMed |
| Alanine aminotransferase levels | A | β 0.009 | 2E-9 | PubMed |
| Body fat distribution (arm fat ratio) | A | β 0.021 | 3E-7 | PubMed |
| Waist-to-hip ratio adjusted for body mass index | G | β 0.068 | 2E-6 | PubMed |
| Low density lipoprotein cholesterol levels | A | β 0.018 | 3E-6 | PubMed |
| Body fat distribution (trunk fat ratio) | A | β 0.012 | 6E-6 | PubMed |
Sources
- dbSNP: rs351855 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- NCBI Gene: FGFR4
- Ensembl: FGFR4
- GWAS Catalog — association studies