Genetic variant
rs34983651
rs34983651 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs34983651 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs34983651 is one of four SNPs all describing an insertion/deletion polymorphism in the promoter reg...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs34983651, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs34983651
- Position
- chr2:233760233
Genome-wide association studies (10)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Angiopoietin-related protein 1 levels (ANGPTL1.9092.33.3) | CAT | OR 0.55 | 2E-102 | PubMed |
| Direct bilirubin levels x insomnia interaction | — | — | 1E-67 | PubMed |
| Total bilirubin levels x insomnia interaction | — | — | 1E-67 | PubMed |
| UDP-glucuronosyltransferase 1-6 levels (UGT1A6.7891.45.3) | CAT | OR 0.31 | 2E-30 | PubMed |
| Protein-tyrosine kinase 6 levels (PTK6.3832.51.1) | CAT | OR 0.22 | 1E-16 | PubMed |
| Cholesterol levels (UKB data field 30690) | CAT | β 0.017 | 1E-14 | PubMed |
| Total cholesterol levels | CAT | β 0.018 | 2E-14 | PubMed |
| Testis-specific chromodomain protein Y 1 levels (CDY1.7097.8.3) | CAT | OR 0.21 | 2E-14 | PubMed |
| Retinol dehydrogenase 16 levels (RDH16.12881.17.3) | CAT | OR 0.2 | 1E-13 | PubMed |
| Thyroxine levels | CAT | OR 0.11 | 1E-11 | PubMed |
Sources
- dbSNP: rs34983651 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies