Genetic variant
rs34536443
rs34536443 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs34536443 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs34536443, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs34536443
- Position
- chr19:10352442
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Platelet count | C | β 0.095 | 3E-47 | PubMed |
| IFNAR1 protein levels | C | OR 0.17 | 5E-41 | PubMed |
| Platelet crit (UKB data field 30090) | C | β 0.056 | 7E-39 | PubMed |
| Platelet count | C | β 0.062 | 1E-38 | PubMed |
| IL12RB1 protein levels | C | OR 0.16 | 4E-38 | PubMed |
| Platelet count | C | — | 8E-37 | PubMed |
| Platelet count (UKB data field 30080) | C | β 0.052 | 7E-35 | PubMed |
| Plateletcrit | C | β 0.069 | 8E-35 | PubMed |
| Hypothyroidism | C | OR 0.12 | 9E-35 | PubMed |
| Hypothyroidism | C | OR 0.11 | 9E-32 | PubMed |
| Psoriasis | G | OR 1.88 | 9E-31 | PubMed |
| Psoriasis (PheCode 696.4) | G | OR 0.36 | 1E-30 | PubMed |
| Platelet count | C | β 0.064 | 1E-30 | PubMed |
| Rheumatoid arthritis | C | OR 0.75 | 3E-29 | PubMed |
| Psoriasis vulgaris (PheCode 696.41) | G | OR 0.36 | 3E-29 | PubMed |
| Psoriasis or type 2 diabetes (trans-disease meta-analysis) | G | OR 1.41 | 8E-29 | PubMed |
| COVID-19 (critical illness vs population) | C | OR 1.5 | 2E-28 | PubMed |
| Psoriasis (PheCode 696.4) | G | OR 0.36 | 2E-28 | PubMed |
| Psoriasis and related disorder (PheCode 696) | G | OR 0.33 | 4E-28 | PubMed |
| Autoimmune traits | — | — | 4E-28 | PubMed |
Sources
- dbSNP: rs34536443 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies