Genetic variant

rs326

rs326 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs326 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

The (A) allele of rs326 was associated with risk for lower high-density lipoprotein (HDL) cholestero...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs326, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs326
Position
chr8:19961928

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Triglycerides A OR 0.11 7E-163 PubMed
High density lipoprotein cholesterol levels A OR 0.11 2E-125 PubMed
Triglyceride levels — β 0.059 1E-43 PubMed
HDL cholesterol levels G OR 0.17 1E-41 PubMed
High density lipoprotein cholesterol levels — OR 1.5 2E-36 PubMed
Metabolic syndrome A OR 0.16 2E-33 PubMed
Total cholesterol to total lipids ratio in medium VLDL A β 0.045 2E-24 PubMed
Free Cholesterol to Total Lipids in Small HDL percentage G β 0.028 2E-21 PubMed
Low high density lipoprotein cholesterol levels — — 5E-18 PubMed
Cholesterol in Medium LDL G β 0.02 9E-14 PubMed
Cholesterol in Small LDL G β 0.02 2E-13 PubMed
Sphingomyelin_38:1_[M+H]1+ levels G β 0.092 3E-13 PubMed
Diacylglycerol_36:3_[M+H-H2O]1+ levels G β 0.083 5E-13 PubMed
Diacylglycerol_34:2_[M+H-H2O]1+ levels G β 0.079 2E-12 PubMed
Phosphatidylcholine_34:0_[M+H]1+/Phosphatidylethanolamine_37:0_[M+H]1+/Phosphatidate_39:1_[M+NH4]1+ levels G β 0.087 4E-12 PubMed
Triacylglycerol_52:3_[M+NH4]1+ levels G OR 0.11 4E-12 PubMed
Triglycerides A OR 6.6 5E-12 PubMed
Phosphatidylcholine-O_34:1_[M+H]1+/Phosphatidylcholine-P_34:0_[M+H]1+/Phosphatidylethanolamine-O_37:1_[M+H]1+ levels G β 0.084 7E-12 PubMed
Triglyceride levels A β 0.096 2E-11 PubMed
Phosphatidylcholine-O_32:1_[M+H]1+/Phosphatidylcholine-P_32:0_[M+H]1+/Phosphatidylethanolamine-O_35:1_[M+H]1+ levels G β 0.085 2E-11 PubMed

Sources