Genetic variant

rs325

rs325 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs325 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs325, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs325
Position
chr8:19961817

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Monounsaturated fatty acids to total fatty acids percentage C OR 0.18 2E-715 PubMed
Monounsaturated fatty acids to total fatty acids percentage C — 1E-300 PubMed
Triglyceride levels C OR 0.18 7E-263 PubMed
Triglycerides x physical activity interaction (2df test) T — 4E-227 PubMed
Cholesteryl Esters to Total Lipids in Small VLDL percentage C β 0.1 4E-206 PubMed
Monounsaturated fatty acids to total fatty acids percentage C — 1E-177 PubMed
Monounsaturated fatty acids to total fatty acids percentage C — 1E-167 PubMed
Sphingomyelins levels C β 0.08 1E-155 PubMed
Cholesteryl Esters to Total Lipids in Large VLDL percentage C β 0.09 6E-154 PubMed
Average diameter for VLDL particles (UKB data field 23431) C OR 0.19 3E-147 PubMed
Phospholipids to Total Lipids in Large LDL percentage C OR 0.13 3E-145 PubMed
Polyunsaturated fatty acids to monounsaturated fatty acids ratio C — 6E-144 PubMed
Free Cholesterol to Total Lipids in Very Small VLDL percentage C β 0.09 3E-142 PubMed
Polyunsaturated fatty acids to monounsaturated fatty acids ratio C — 4E-141 PubMed
Triglycerides in large VLDL (UKB data field 23501) C OR 0.19 2E-134 PubMed
Cholesteryl esters to total lipids in medium VLDL percentage (UKB data field 23596) C OR 0.18 2E-124 PubMed
Degree of unsaturation C — 1E-123 PubMed
Cholesterol to total lipids in medium VLDL percentage (UKB data field 23595) C OR 0.17 1E-111 PubMed
Cholesteryl esters in large HDL (UKB data field 23562) C OR 0.15 3E-107 PubMed
Cholesterol in large HDL (UKB data field 23561) C OR 0.15 4E-103 PubMed

Sources