Genetic variant
rs322351
rs322351 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs322351 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
MAP kinase genes and colon and rectal cancer
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs322351, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs322351
- Position
- chr5:172767870
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| mean corpuscular hemoglobin (MCH, mean, inv-norm transformed) | C | β 0.041 | 5E-46 | PubMed |
| mean corpuscular hemoglobin (MCH, maximum, inv-norm transformed) | C | β 0.039 | 1E-43 | PubMed |
| mean corpuscular volume (MCV, mean, inv-norm transformed) | C | β 0.034 | 3E-35 | PubMed |
| mean corpuscular hemoglobin (MCH, minimum, inv-norm transformed) | C | β 0.035 | 4E-35 | PubMed |
| Mean corpuscular hemoglobin | T | — | 1E-32 | PubMed |
| mean corpuscular volume (MCV, maximum, inv-norm transformed) | C | β 0.033 | 2E-32 | PubMed |
| Mean corpuscular hemoglobin | T | β 0.023 | 3E-31 | PubMed |
| mean corpuscular volume (MCV, minimum, inv-norm transformed) | C | β 0.031 | 5E-29 | PubMed |
| Mean corpuscular volume | T | — | 5E-28 | PubMed |
| Mean corpuscular volume | T | β 0.02 | 4E-27 | PubMed |
| Mean corpuscular hemoglobin | — | — | 5E-27 | PubMed |
| mean corpuscular hemoglobin (MCH, mean, inv-norm transformed) | C | β 0.034 | 2E-23 | PubMed |
| Mean corpuscular hemoglobin | T | β 0.02 | 1E-22 | PubMed |
| mean corpuscular hemoglobin (MCH, minimum, inv-norm transformed) | C | β 0.03 | 7E-20 | PubMed |
| Mean corpuscular volume | T | β 0.018 | 4E-19 | PubMed |
| Mean corpuscular volume | C | β 0.1 | 5E-19 | PubMed |
| Red cell distribution width | C | β 0.015 | 5E-16 | PubMed |
| Red cell distribution width | C | — | 3E-14 | PubMed |
| mean corpuscular hemoglobin concentration (MCHC, mean, inv-norm transformed) | C | β 0.018 | 1E-11 | PubMed |
| Red blood cell count | T | β 0.009 | 2E-11 | PubMed |
Sources
- dbSNP: rs322351 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies