Genetic variant
rs320
rs320 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs320 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs320, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs320
- Position
- chr8:19961566
Genome-wide association studies (7)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Diacylglycerol_36:3_[M+H-H2O]1+ levels | G | β 0.083 | 1E-12 | PubMed |
| Phosphatidylcholine_34:0_[M+H]1+/Phosphatidylethanolamine_37:0_[M+H]1+/Phosphatidate_39:1_[M+NH4]1+ levels | G | β 0.088 | 9E-12 | PubMed |
| Triacylglycerol_52:3_[M+NH4]1+ levels | G | OR 0.11 | 3E-11 | PubMed |
| Sphingomyelin_38:1_[M+H]1+ levels | G | β 0.085 | 4E-11 | PubMed |
| Diacylglycerol_34:2_[M+H-H2O]1+ levels | G | β 0.075 | 6E-11 | PubMed |
| Diacylglycerol_36:2_[M+H-H2O]1+ levels | G | β 0.074 | 1E-10 | PubMed |
| Phosphatidylcholine_34:1_[M+H]1+/Phosphatidylethanolamine_37:1_[M+H]1+/Phosphatidate_39:2_[M+NH4]1+ levels | G | β 0.083 | 1E-10 | PubMed |
Sources
- dbSNP: rs320 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies