Genetic variant
rs3181077
rs3181077 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs3181077 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A Polymorphism in CCR1/CCR3 Is Associated with Narcolepsy
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs3181077, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs3181077
- Position
- chr3:46209161
Genome-wide association studies (10)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Basophil count | T | β 0.045 | 3E-72 | PubMed |
| Basophil percentage of white cells | T | β 0.042 | 2E-66 | PubMed |
| Basophil count | T | β 0.037 | 2E-59 | PubMed |
| Basophil count | T | — | 5E-57 | PubMed |
| CCL11 protein levels | T | β 0.077 | 4E-40 | PubMed |
| Basophil percentage of white cells | T | β 0.035 | 4E-20 | PubMed |
| White blood cell count (basophil) | T | β 0.035 | 1E-19 | PubMed |
| Basophil count | T | β 0.019 | 7E-19 | PubMed |
| Basophil percentage of granulocytes | T | β 0.032 | 2E-16 | PubMed |
| Narcolepsy with cataplexy | T | OR 1.63 | 6E-6 | PubMed |
Sources
- dbSNP: rs3181077 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies