Genetic variant
rs3117582
rs3117582 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs3117582 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
lung cancer rs3117582 P = 4.97 x 10(-10) Update in lung cancer 2008. Potential etiologic and functio...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs3117582, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs3117582
- Position
- chr6:31652743
Genome-wide association studies (11)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) | C | — | 1E-30 | PubMed |
| Seropositivity for streptococcus agalactiae peptide (agilent_241118) | — | OR 10.8 | 3E-27 | PubMed |
| Seropositivity for streptococcus pyogenes peptide (agilent_220658) | — | OR 9.61 | 7E-22 | PubMed |
| Seropositivity for staphylococcus aureus peptide (agilent_222381) | — | OR 8.62 | 7E-18 | PubMed |
| Seropositivity for staphylococcaceae peptide (agilent_4825) | — | OR 7.6 | 3E-14 | PubMed |
| Lung adenocarcinoma | C | OR 1.22 | 5E-12 | PubMed |
| Inguinal hernia | T | OR 1.11 | 3E-10 | PubMed |
| Lung cancer | — | OR 1.24 | 4E-10 | PubMed |
| Lung cancer | C | OR 1.24 | 5E-10 | PubMed |
| Squamous cell lung carcinoma | G | OR 0.77 | 2E-9 | PubMed |
| Non-small cell lung cancer | G | OR 0.87 | 2E-6 | PubMed |
Sources
- dbSNP: rs3117582 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies