Genetic variant
rs2854746
rs2854746 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2854746 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2854746, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2854746
- Position
- chr7:45921046
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Serum levels of protein IGFALS | C | OR 0.53 | 2E-189 | PubMed |
| Nutritionally-regulated adipose and cardiac enriched protein homolog levels | C | OR 0.38 | 1E-182 | PubMed |
| IGF 1 (UKB data field 30770) | C | β 0.04 | 1E-104 | PubMed |
| Insulin-like growth factor-binding protein 3 levels | C | OR 0.23 | 8E-78 | PubMed |
| Insulin-like growth factor-binding protein 3 levels | — | OR 0.42 | 3E-52 | PubMed |
| Insulin-like growth factor-binding protein 3 levels | C | OR 0.4 | 1E-49 | PubMed |
| IGF2 protein levels | — | OR 0.48 | 2E-49 | PubMed |
| IGFBP3 protein levels | — | OR 0.48 | 3E-49 | PubMed |
| Insulin-like growth factor-binding protein complex acid labile subunit levels | C | OR 0.19 | 3E-48 | PubMed |
| diastolic blood pressure (DBP, mean, inv-normal transformed) | G | β 0.027 | 6E-24 | PubMed |
| Diastolic blood pressure | C | OR 0.23 | 1E-19 | PubMed |
| Insulin-like growth factor I levels | — | OR 0.24 | 1E-17 | PubMed |
| diastolic blood pressure (DBP, mean, inv-normal transformed) | G | β 0.022 | 4E-15 | PubMed |
| Vertex-wise cortical thickness | C | OR 7.31 | 3E-13 | PubMed |
| Diastolic blood pressure | — | β 0.014 | 1E-11 | PubMed |
| Coronary artery calcification | C | OR 0.11 | 5E-10 | PubMed |
| Height (baseline) | G | β 0.008 | 2E-9 | PubMed |
| Volume of right cortico-amygdaloid transition area | C | β 0.035 | 1E-8 | PubMed |
| IGFBP 3 plasma levels | G | β 0.095 | 1E-7 | PubMed |
| Coronary artery calcification | — | — | 4E-6 | PubMed |
Sources
- dbSNP: rs2854746 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies