Genetic variant
rs2744475
rs2744475 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2744475 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Crying 23andMe *rs62335062 (P=2.6x10-31, OR=1.111) upstream of IRX2 *rs7196282 (P=5.0x10-14, OR=0.92...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2744475, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2744475
- Position
- chr6:50817167
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Weight (mean, inv-normal transformed) | C | β 0.046 | 2E-43 | PubMed |
| Body mass index | G | β 0.045 | 7E-40 | PubMed |
| Body mass index (BMI, maximum, inv-normal transformed) | C | β 0.049 | 5E-24 | PubMed |
| Weight (maximum, inv-normal transformed) | C | β 0.048 | 1E-23 | PubMed |
| Body mass index (BMI, mean, inv-normal transformed) | C | β 0.049 | 1E-22 | PubMed |
| Weight (mean, inv-normal transformed) | C | β 0.046 | 6E-22 | PubMed |
| Hand grip strength | C | β 0.003 | 2E-20 | PubMed |
| What is your weight? (pounds, inv-normal transformed) | C | β 0.034 | 7E-20 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | C | β 0.025 | 1E-18 | PubMed |
| Weight (minimum, inv-normal transformed) | C | β 0.042 | 2E-17 | PubMed |
| Body mass index (BMI, minimum, inv-normal transformed) | C | β 0.042 | 3E-17 | PubMed |
| Hand grip strength | G | β 0.003 | 7E-17 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | C | β 0.022 | 2E-15 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | C | β 0.021 | 3E-14 | PubMed |
| Body mass index | — | OR 0.14 | 2E-13 | PubMed |
| Body mass index | C | β 0.006 | 7E-12 | PubMed |
| Type 2 diabetes (PheCode 250.2) | C | β 0.036 | 1E-11 | PubMed |
| Waist circumference | — | OR 0.29 | 2E-9 | PubMed |
| Body fat percentage | — | OR 0.19 | 4E-9 | PubMed |
| Hip circumference | — | OR 0.2 | 6E-9 | PubMed |
Sources
- dbSNP: rs2744475 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies