Genetic variant

rs2727271

rs2727271 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2727271 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2727271, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs2727271
Position
chr11:61835886

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Cholesterol to Total Lipids in Very Small VLDL percentage T OR 0.11 2E-142 PubMed
Cholesterol to Total Lipids in Very Small VLDL percentage T β 0.069 5E-50 PubMed
1-palmitoleoyl-2-linoleoyl-GPC (16:1/18:2) levels T OR 0.34 2E-24 PubMed
Sterol ester (27:1/20:3) levels T OR 0.17 4E-19 PubMed
Cholesteryl esters in medium HDL (UKB data field 23569) T β 0.061 8E-19 PubMed
Concentration of HDL particles (UKB data field 23430) T β 0.059 2E-17 PubMed
Non-albumin protein levels — β 0.037 2E-13 PubMed
1-oleoyl-2-docosapentaenoyl-GPC (18:1/22:5n3) levels T OR 0.15 6E-13 PubMed
Phosphatidylcholine(42:4)_[M+OAc]1- levels T β 0.042 1E-12 PubMed
Phosphatidylcholine-O(40:5)_[M+H]1+/Phosphatidylcholine-P(40:4)_[M+H]1+ levels T OR 0.13 1E-12 PubMed
Triacylglycerol(58:9)_[M+NH4]1+ levels A OR 0.12 1E-12 PubMed
Phosphatidylcholine(38:4)_[M+OAc]1-/Phosphatidylserine(42:3)_[M-H]1- levels C β 0.062 1E-12 PubMed
Phosphatidylinositol(36:2)_[M-H]1- levels T β 0.083 1E-12 PubMed
Phosphatidylinositol-O(36:0)_[M-H]1-/Phosphatidylglycerol(37:0)_[M+OAc]1- levels C β 0.042 1E-12 PubMed
Phosphatidylcholine(36:3)_[M+OAc]1-/Phosphatidylserine(40:2)_[M-H]1- levels C OR 0.12 1E-12 PubMed
Phosphatidylcholine(36:5)_[M+OAc]1-/Phosphatidylserine(40:4)_[M-H]1- levels A β 0.043 1E-12 PubMed
Phosphatidylcholine(40:5)_[M+H]1+ levels G β 0.06 1E-12 PubMed
Phosphatidylcholine(40:6)_[M+H]1+/Phosphatidylethanolamine(43:6)_[M+H]1+ levels T β 0.061 1E-12 PubMed
Sphingomyelin(44:9)_[M+H]1- levels G β 0.076 1E-12 PubMed
Phosphatidylcholine(38:4)_[M+H]1+/Phosphatidylethanolamine(41:4)_[M+H]1+ levels G β 0.068 1E-12 PubMed

Sources