Genetic variant

rs261334

rs261334 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs261334 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs261334, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs261334
Position
chr15:58434545

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Triglycerides to total lipids ratio in chylomicrons and extremely large VLDL C OR 0.16 1E-224 PubMed
Phospholipids to total lipids ratio in large VLDL G OR 0.13 1E-166 PubMed
Monounsaturated fatty acid levels G — 7E-135 PubMed
Phosphatidylcholine_33:4_[M+H]1+/Phosphatidylethanolamine_36:4_[M+H]1+/Phosphatidate_38:5_[M+NH4]1+ levels G OR 0.35 2E-132 PubMed
Triglyceride levels in very large HDL — OR 0.27 1E-125 PubMed
High density lipoprotein cholesterol levels G OR 0.1 3E-118 PubMed
Phosphatidylcholine_35:4_[M+H]1+/Phosphatidylethanolamine_38:4_[M+H]1+/Phosphatidate_40:5_[M+NH4]1+ levels G OR 0.32 1E-115 PubMed
Phosphatidylethanolamine_38:6_[M-H]1- levels G OR 0.32 4E-114 PubMed
Cholesteryl esters to total lipids ratio in very small VLDL C OR 0.11 2E-113 PubMed
1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4) levels G OR 0.41 2E-112 PubMed
Total lipid levels in IDL G OR 0.11 3E-109 PubMed
Phosphatidylcholine_35:6_[M+H]1+/Phosphatidylethanolamine_38:6_[M+H]1+/Phosphatidate_40:7_[M+NH4]1+ levels G OR 0.32 6E-105 PubMed
Linoleic acid levels G — 4E-104 PubMed
Phosphatidylethanolamine_36:4_[M-H]1- levels G OR 0.3 3E-103 PubMed
Saturated fatty acid levels G OR 0.11 8E-100 PubMed
Saturated fatty acids levels G — 1E-93 PubMed
Omega-6 fatty acids to total fatty acids percentage G — 4E-93 PubMed
Total lipid levels in lipoprotein particles G β 0.099 3E-89 PubMed
Omega-3 fatty acids to Omega-6 fatty acids ratio G — 8E-87 PubMed
Concentration of VLDL particles G β 0.094 1E-78 PubMed

Sources