Genetic variant
rs2576452
rs2576452 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2576452 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2576452, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2576452
- Position
- chr19:54172738
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| 1-palmitoyl-2-oleoyl-GPI (16:0/18:1) levels | C | OR 0.27 | 2E-46 | PubMed |
| Arachidonate 20:4n6-to-1-arachidonoylglycerophosphoinositol ratio | T | β 0.028 | 2E-29 | PubMed |
| 1-palmitoleoyl-GPI (16:1) levels | C | OR 0.24 | 4E-28 | PubMed |
| Omega-3 fatty acids to total fatty acids percentage | T | — | 1E-23 | PubMed |
| Docosahexaenoic acid levels | T | — | 3E-23 | PubMed |
| CES3 protein levels | T | β 0.054 | 2E-22 | PubMed |
| Omega-3 fatty acids to Omega-6 fatty acids ratio | T | — | 9E-20 | PubMed |
| Omega-3 fatty acid levels | T | — | 4E-19 | PubMed |
| CES1 protein levels | T | β 0.043 | 1E-16 | PubMed |
| Lysophosphatidylinositol (18:0) [sn1] levels | T | OR 0.17 | 1E-13 | PubMed |
| Phosphatidylinositol(38:4)_[M-H]1- levels | A | β 0.043 | 7E-13 | PubMed |
| Phosphatidylinositol(40:5)_[M-H]1- levels | G | OR 0.19 | 7E-13 | PubMed |
| Phosphatidylinositol(40:6)_[M-H]1- levels | A | β 0.039 | 7E-13 | PubMed |
| Phosphatidylinositol(38:6)_[M-H]1- levels | G | OR 0.19 | 7E-13 | PubMed |
| Phosphatidate(44:6)_[M+OAc]1-/Phosphatidylglycerol(43:6)_[M-H]1- levels | T | OR 0.19 | 7E-13 | PubMed |
| Phosphatidylinositol(36:2)_[M-H]1- levels | A | β 0.087 | 7E-13 | PubMed |
| Phosphatidylinositol(35:2)_[M-H]1- levels | C | β 0.048 | 7E-13 | PubMed |
| Phosphatidylinositol(34:0)_[M-H]1- levels | A | β 0.04 | 7E-13 | PubMed |
| Phosphatidylinositol(34:1)_[M-H]1- levels | T | OR 0.19 | 7E-13 | PubMed |
| Phosphatidylinositol(34:2)_[M-H]1- levels | A | β 0.077 | 7E-13 | PubMed |
Sources
- dbSNP: rs2576452 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies