Genetic variant

rs2575876

rs2575876 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2575876 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2575876, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs2575876
Position
chr9:104903458

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
HDL cholesterol levels A OR 0.11 2E-201 PubMed
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) A — 9E-154 PubMed
Total cholesterol levels A β 0.067 4E-97 PubMed
HDL cholesterol levels in current drinkers A β 0.019 8E-93 PubMed
High density lipoprotein cholesterol levels — β 0.094 2E-86 PubMed
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) A — 2E-81 PubMed
HDL cholesterol levels A OR 1.42 5E-64 PubMed
Free Cholesterol to Total Lipids in Very Large HDL percentage A β 0.051 3E-62 PubMed
Total cholesterol levels — — 1E-59 PubMed
total cholesterol (maximum, inv-norm transformed) G β 0.048 1E-56 PubMed
Triglycerides in very large HDL A β 0.073 1E-53 PubMed
Total cholesterol levels — OR 3.03 4E-51 PubMed
Total cholesterol levels — β 0.058 9E-51 PubMed
HDL cholesterol x physical activity interaction (2df test) A — 9E-51 PubMed
Sphingomyelins levels A β 0.069 2E-44 PubMed
Total cholesterol levels A β 0.055 3E-43 PubMed
Apolipoprotein A-I levels A β 0.062 8E-40 PubMed
HDL cholesterol levels x long total sleep time interaction (2df test) — β 0.013 9E-40 PubMed
Cholesteryl Esters to Total Lipids in Small VLDL percentage A β 0.03 9E-39 PubMed
HDL cholesterol levels x short total sleep time interaction (2df test) — β 0.013 2E-38 PubMed

Sources