Genetic variant
rs2472297
rs2472297 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2472297 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs2472297 is a SNP located between the CYP1A1 and CYP1A2 genes on ch 15q24. A meta-analysis of four ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2472297, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2472297
- Position
- chr15:74735539
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Caffeine consumption from coffee or tea | C | OR 0.1 | 2E-351 | PubMed |
| Coffee consumption (cups per day) | C | β 0.069 | 1E-182 | PubMed |
| Coffee consumption | T | β 0.045 | 9E-157 | PubMed |
| Caffeine consumption from coffee | C | β 0.065 | 3E-140 | PubMed |
| Caffeine consumption from tea | C | β 0.054 | 3E-102 | PubMed |
| Bitter non-alcoholic beverage consumption | T | β 0.039 | 1E-97 | PubMed |
| Coffee consumption (cups per day) | T | OR 0.14 | 2E-95 | PubMed |
| Bitter beverage consumption | T | β 0.033 | 4E-74 | PubMed |
| Estimated glomerular filtration rate (creatinine) | T | OR 14.75 | 3E-49 | PubMed |
| Tea consumption | T | β 0.025 | 1E-45 | PubMed |
| Creatinine levels (UKB data field 30700) | T | β 0.022 | 7E-37 | PubMed |
| Tea consumption | C | β 0.017 | 2E-36 | PubMed |
| Estimated glomerular filtration rate (creatinine) | C | β 0.004 | 6E-35 | PubMed |
| Estimated glomerular filtration rate | T | β 0.004 | 1E-34 | PubMed |
| Creatinine levels | T | β 0.033 | 5E-34 | PubMed |
| Estimated glomerular filtration rate | T | β 0.004 | 8E-34 | PubMed |
| F-chocolate/coffee liking (derived food-liking factor) | T | OR 0.2 | 1E-33 | PubMed |
| Caffeine levels | T | OR 0.25 | 1E-32 | PubMed |
| Urinary albumin-to-creatinine ratio | T | β 0.027 | 2E-32 | PubMed |
| Estimated glomerular filtration rate | T | β 0.032 | 2E-32 | PubMed |
Sources
- dbSNP: rs2472297 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies