RS2297595 DPYD

Drug Response Chr 1:97699534 snv missense variant
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What This Variant Does
"CLNSIG=6
Associated Conditions
Dihydropyrimidine dehydrogenase deficiency
capecitabine response - Toxicity
fluorouracil response - Toxicity
DPYD-related disorder
Colorectal cancer
Adrenocortical carcinoma
hereditary
Dihydropyrimidine dehydrogenase deficiency
capecitabine response - Toxicity
fluorouracil response - Toxicity
DPYD-related disorder
Colorectal cancer
Adrenocortical carcinoma
hereditary
Population Frequencies
gnomAD ALL
9%
1kG AFR
96.9%
1kG ALL
5.7%
1kG AMR
6.3%
1kG EAS
1.8%
1kG EUR
11.9%
1kG SAS
6.1%
Other Variants in DPYD
rs59086055 rs56005131 rs67376798 rs55886062 rs115232898 rs1801160 rs56038477 rs1801158 rs17376848 rs1801159
Ask Dr. Hemsworth about this variant