Genetic variant
rs2237897
rs2237897 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2237897 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
nature type-2 diabetes *rs2237897, P = 6.8 times 10-13
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2237897, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2237897
- Position
- chr11:2837316
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Type 2 diabetes | C | — | 3E-485 | PubMed |
| Type 2 diabetes | C | OR 1.28 | 2E-245 | PubMed |
| Type 2 diabetes | C | OR 0.22 | 2E-226 | PubMed |
| Type 2 diabetes | T | OR 0.27 | 1E-196 | PubMed |
| Type 2 diabetes | T | OR 0.24 | 9E-191 | PubMed |
| Type 2 diabetes | T | OR 0.28 | 3E-184 | PubMed |
| Type 2 diabetes | C | OR 0.26 | 8E-171 | PubMed |
| Type 2 diabetes | C | OR 1.3 | 3E-168 | PubMed |
| Type 2 diabetes | T | OR 0.79 | 3E-168 | PubMed |
| Fasting blood glucose | T | β 0.052 | 5E-138 | PubMed |
| Medication use (drugs used in diabetes) | T | OR 0.25 | 2E-127 | PubMed |
| Medication use (drugs used in diabetes) | T | OR 0.25 | 2E-127 | PubMed |
| Type 2 diabetes (PheCode 250.2) | — | OR 0.21 | 1E-103 | PubMed |
| Type 2 diabetes (PheCode 250.2) | — | — | 3E-93 | PubMed |
| Diabetes mellitus (PheCode 250) | — | — | 2E-90 | PubMed |
| Type 2 diabetes | C | OR 1.15 | 2E-70 | PubMed |
| Type 2 diabetes (PheCode 250.2) | C | OR 0.16 | 7E-60 | PubMed |
| Diabetes mellitus (PheCode 250) | C | OR 0.16 | 1E-58 | PubMed |
| Hemoglobin A1c (HbA1c, maximum, inv-norm transformed) | C | β 0.09 | 2E-58 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | C | β 0.081 | 2E-58 | PubMed |
Sources
- dbSNP: rs2237897 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies