Genetic variant
rs2156552
rs2156552 is a single-letter difference in human DNA, on chromosome 18. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2156552 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2156552, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2156552
- Position
- chr18:49655298
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| High density lipoprotein cholesterol levels | — | — | 2E-389 | PubMed |
| High-density lipoprotein levels | A | β 0.083 | 3E-327 | PubMed |
| HDL cholesterol | T | β 0.081 | 3E-194 | PubMed |
| HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) | T | — | 6E-106 | PubMed |
| HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) | T | — | 5E-92 | PubMed |
| Phospholipids in medium HDL | A | OR 0.1 | 4E-82 | PubMed |
| Concentration of medium HDL particles | A | OR 0.1 | 4E-79 | PubMed |
| Total lipids in medium HDL | A | β 0.099 | 9E-77 | PubMed |
| HDL cholesterol levels | A | β 0.079 | 2E-74 | PubMed |
| Phospholipid levels in small HDL | A | β 0.087 | 7E-60 | PubMed |
| Phospholipids to total lipids ratio in small HDL | A | β 0.084 | 3E-59 | PubMed |
| HDL cholesterol levels in current drinkers | T | β 0.019 | 2E-58 | PubMed |
| Triglyceride levels in large HDL | A | β 0.079 | 2E-53 | PubMed |
| Phospholipids to total lipids in small HDL percentage (UKB data field 23644) | A | β 0.086 | 4E-47 | PubMed |
| High density lipoprotein cholesterol levels | A | β 0.066 | 7E-45 | PubMed |
| Free Cholesterol to Total Lipids in Large VLDL percentage | T | β 0.04 | 2E-44 | PubMed |
| Saturated fatty acids levels | A | — | 7E-40 | PubMed |
| Triglyceride levels in medium HDL | A | β 0.065 | 6E-35 | PubMed |
| Omega-6 fatty acid levels | A | — | 2E-34 | PubMed |
| Phospholipids in small HDL | A | β 0.063 | 9E-32 | PubMed |
Sources
- dbSNP: rs2156552 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies