Genetic variant
rs2074238
rs2074238 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2074238 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
23andMe blog Influences QT interval [GWAS:QT interval]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2074238, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2074238
- Position
- chr11:2463573
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| QT interval | T | OR 0.26 | 4E-400 | PubMed |
| JT interval | T | OR 0.27 | 6E-400 | PubMed |
| QT interval | T | OR 3.58 | 8E-130 | PubMed |
| Electrocardiogram morphology (amplitude at temporal datapoints) | T | OR 0.23 | 4E-123 | PubMed |
| QTc interval | — | OR 4.68 | 1E-117 | PubMed |
| QT interval | T | OR 0.23 | 1E-106 | PubMed |
| ECG latent space | — | — | 2E-75 | PubMed |
| ECG cardiac MRI latent space | — | — | 2E-63 | PubMed |
| QT interval | T | OR 0.17 | 8E-63 | PubMed |
| T wave morphology restitution during recovery from exercise | T | OR 0.14 | 1E-59 | PubMed |
| T wave morphology restitution during recovery from exercise (MTAG) | T | OR 0.17 | 5E-58 | PubMed |
| T wave morphology restitution during exercise (MTAG) | T | OR 0.12 | 7E-34 | PubMed |
| QT interval | T | OR 4.89 | 2E-28 | PubMed |
| QT interval | C | OR 5.41 | 7E-28 | PubMed |
| QT interval | T | OR 7.88 | 3E-17 | PubMed |
| QT interval | — | OR 4.78 | 2E-12 | PubMed |
| 12-lead ECG morphology phenotype | — | — | 9E-12 | PubMed |
| T amplitude of combined wave in lead V2 | — | — | 3E-10 | PubMed |
| T amplitude of combined wave in lead V1 | — | — | 3E-10 | PubMed |
| T amplitude of combined wave in lead V3 | — | — | 3E-10 | PubMed |
Sources
- dbSNP: rs2074238 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies