RS2066718 ABCA1
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What This Variant Does
"ABCA1 rs2230805 and rs2230806 common gene variants are associated with Alzheimer's disease."
Associated Conditions
Tangier disease
Hypoalphalipoproteinemia
primary
1
Tangier disease
Hypoalphalipoproteinemia
primary
1
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Apolipoprotein A1 levels | T | OR: 0.12 | 3E-63 | PubMed |
| High density lipoprotein cholesterol levels | T | OR: 0.11 | 1E-49 | PubMed |
| Cholesterol to Total Lipids in Large LDL percentage | T | β: 0.08 | 9E-41 | PubMed |
| Phospholipids to total lipids ratio in medium HDL | C | OR: 0.12 | 2E-25 | PubMed |
| Linoleic acid to total fatty acids percentage | T | β: 0.05 | 1E-18 | PubMed |
| Free cholesterol to total lipids ratio in medium HDL | C | β: 0.093 | 1E-17 | PubMed |
| Cholesterol to total lipids ratio in large LDL | C | OR: 0.1 | 2E-17 | PubMed |
| Free cholesterol to total lipids ratio in small HDL | C | β: 0.095 | 4E-16 | PubMed |
| HDL cholesterol levels | C | β: 0.082 | 6E-14 | PubMed |
| Total cholesterol to total lipids ratio in very large HDL | T | β: 0.092 | 9E-14 | PubMed |
| Cholesteryl ester levels in HDL | C | β: 0.082 | 1E-13 | PubMed |
| Total cholesterol levels | T | β: 0.05 | 8E-13 | PubMed |
| Cholesteryl esters to total lipids ratio in very large HDL | T | β: 0.088 | 1E-12 | PubMed |
| Free Cholesterol to Total Lipids in Medium LDL percentage | T | β: 0.04 | 2E-12 | PubMed |
| Cholesterol to Total Lipids in IDL percentage | T | β: 0.04 | 5E-12 | PubMed |
| Phospholipids to total lipids ratio in very large HDL | T | β: 0.085 | 1E-11 | PubMed |
| Cholesteryl Esters to Total Lipids in IDL percentage | T | β: 0.04 | 2E-11 | PubMed |
| Cholesterol to Total Lipids in Small HDL percentage | T | β: 0.04 | 2E-11 | PubMed |
| Linoleic acid to total fatty acids percentage | T | — | 3E-11 | PubMed |
| Triglycerides to total lipids ratio in large VLDL | C | β: 0.076 | 5E-10 | PubMed |
Other Variants in ABCA1