Genetic variant
rs2036527
rs2036527 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2036527 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2036527, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2036527
- Position
- chr15:78559273
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Lung cancer | A | OR 1.26 | 8E-179 | PubMed |
| Lung adenocarcinoma (conditioned on cigarettes per day) | A | OR 1.26 | 3E-82 | PubMed |
| Chronic airway obstruction (PheCode 496) | G | β 0.1 | 3E-66 | PubMed |
| Chronic bronchitis (PheCode 496.2) | G | OR 0.13 | 2E-44 | PubMed |
| Takes medication for Chronic lung diseases including COPD, Emphysema and Bronchitis? | G | OR 0.14 | 2E-43 | PubMed |
| Cotinine and 3'-hydroxycotinine levels in current smokers | A | OR 0.22 | 3E-28 | PubMed |
| Cotinine levels in current smokers | A | OR 0.22 | 5E-27 | PubMed |
| Biological Father: Cancer, Lung | G | β 0.092 | 6E-19 | PubMed |
| Post bronchodilator FEV1/FVC ratio | A | β 0.015 | 7E-16 | PubMed |
| Post bronchodilator FEV1 | A | β 0.071 | 9E-15 | PubMed |
| Other diseases of lung (PheCode 510) | G | β 0.071 | 4E-12 | PubMed |
| Pre bronchodilator FEV1/FVC ratio | — | β 0.017 | 4E-10 | PubMed |
| Dental caries | A | OR 6.02 | 2E-9 | PubMed |
| Pre bronchodilator FEV1 | — | β 0.08 | 2E-9 | PubMed |
| Smoking behavior | A | β 0.04 | 2E-8 | PubMed |
| Lung cancer in ever smokers | A | OR 1.29 | 5E-7 | PubMed |
| Post bronchodilator FEV1/FVC ratio in COPD | A | β 0.012 | 7E-7 | PubMed |
| Pulmonary function | G | β 0.026 | 7E-7 | PubMed |
Sources
- dbSNP: rs2036527 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies