Genetic variant
rs2011425
rs2011425 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs2011425 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs2011425, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs2011425
- Position
- chr2:233718962
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| X-21441 levels | G | OR 0.36 | 8E-39 | PubMed |
| Serum 25-Hydroxyvitamin D levels | G | β 0.046 | 1E-37 | PubMed |
| Total testosterone levels | T | β 0.025 | 3E-26 | PubMed |
| Bioavailable testosterone levels | T | β 0.038 | 9E-25 | PubMed |
| X-11440 levels | T | OR 0.19 | 9E-25 | PubMed |
| Bioavailable testosterone levels | T | β 0.05 | 6E-20 | PubMed |
| Urine X-21851 levels in chronic kidney disease | G | OR 0.36 | 8E-20 | PubMed |
| Free testosterone levels | — | β 0.055 | 6E-18 | PubMed |
| Pregnenetriol sulfate levels | G | OR 0.34 | 2E-16 | PubMed |
| INSL3 protein levels | G | β 0.062 | 2E-14 | PubMed |
| Pregnenetriol disulfate levels | G | OR 0.3 | 3E-13 | PubMed |
| X-21441 levels | G | OR 0.29 | 4E-12 | PubMed |
| Free testosterone levels | G | β 0 | 1E-11 | PubMed |
| Bioavailable testosterone levels | G | β 0.09 | 5E-11 | PubMed |
| Total testosterone levels | T | β 0.033 | 7E-11 | PubMed |
| Pregnenetriol disulfate levels | G | OR 0.16 | 3E-10 | PubMed |
| Total testosterone levels | G | OR 0.2 | 3E-10 | PubMed |
| Free androgen index | — | β 0.037 | 3E-9 | PubMed |
| Plasma norclozapine levels in treatment-resistant schizophrenia | G | — | 8E-9 | PubMed |
| Testosterone levels | G | β 0.035 | 1E-8 | PubMed |
Sources
- dbSNP: rs2011425 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies