Genetic variant
rs1893592
rs1893592 is a single-letter difference in human DNA, on chromosome 21. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs1893592 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
One of 42 more SNPs associated with rheumatoid arthritis based on a meta-analysis of 30,000 patients...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs1893592, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs1893592
- Position
- chr21:42434957
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Graves' disease | C | OR 0.12 | 1E-14 | PubMed |
| Rheumatoid arthritis | A | OR 1.1 | 2E-13 | PubMed |
| Primary sclerosing cholangitis | A | OR 1.22 | 2E-12 | PubMed |
| Lymphocyte count | C | β 0.015 | 2E-12 | PubMed |
| Autoimmune traits (pleiotropy) | C | — | 5E-12 | PubMed |
| Rheumatoid arthritis | A | OR 1.11 | 7E-12 | PubMed |
| Lymphocyte count (UKB data field 30120) | C | β 0.014 | 1E-11 | PubMed |
| Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) | C | OR 0.91 | 2E-11 | PubMed |
| Rheumatoid arthritis (ACPA-positive) | A | OR 1.12 | 8E-11 | PubMed |
| Celiac disease and Rheumatoid arthritis | — | OR 0.91 | 8E-11 | PubMed |
| Celiac disease | — | OR 1.14 | 9E-11 | PubMed |
| Rheumatoid arthritis | C | OR 0.93 | 1E-10 | PubMed |
| Lymphocyte count | C | β 0.015 | 2E-10 | PubMed |
| Type 1 diabetes | — | OR 1.16 | 2E-9 | PubMed |
| Celiac disease | — | OR 1.14 | 3E-9 | PubMed |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) | — | — | 6E-9 | PubMed |
| Inflammatory bowel disease | C | OR 0.91 | 8E-9 | PubMed |
| Rheumatoid arthritis | A | OR 0.1 | 1E-8 | PubMed |
| Sarcoidosis | A | OR 1.11 | 1E-8 | PubMed |
| Neutrophils and lymphocytes in blood (confirmatory factor analysis Factor 35) | — | — | 2E-8 | PubMed |
Sources
- dbSNP: rs1893592 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies