Genetic variant
rs186021206
rs186021206 is a single-letter difference in human DNA, on chromosome 17. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs186021206 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
This SNP is a proxy for the in/del variants discussed on the ASGR1 page
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs186021206, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs186021206
- Position
- chr17:7166093
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Serum alkaline phosphatase levels | A | OR 1.1 | 5E-1068 | PubMed |
| CR1 protein levels | A | OR 1.32 | 2E-311 | PubMed |
| KEL protein levels | A | OR 1.18 | 5E-279 | PubMed |
| CSF1R protein levels | A | OR 1.26 | 3E-264 | PubMed |
| MSR1 protein levels | A | OR 1.15 | 4E-251 | PubMed |
| ICAM2 protein levels | A | OR 0.41 | 2E-227 | PubMed |
| SIGLEC1 protein levels | A | OR 1.12 | 5E-219 | PubMed |
| FCGR2A protein levels | A | OR 0.87 | 2E-215 | PubMed |
| THBS4 protein levels | A | OR 1.1 | 8E-214 | PubMed |
| Low density lipoprotein cholesterol levels | — | — | 5E-212 | PubMed |
| PLAU protein levels | A | OR 1.12 | 1E-207 | PubMed |
| L1CAM protein levels | A | OR 0.98 | 2E-205 | PubMed |
| HEPACAM2 protein levels | A | OR 0.95 | 1E-200 | PubMed |
| LYVE1 protein levels | A | OR 1.14 | 2E-200 | PubMed |
| CD244 protein levels | A | OR 1.06 | 2E-196 | PubMed |
| CD28 protein levels | A | OR 1.07 | 4E-191 | PubMed |
| CD58 protein levels | A | OR 1.02 | 4E-189 | PubMed |
| CD48 protein levels | A | OR 0.97 | 3E-182 | PubMed |
| IL7R protein levels | A | OR 0.36 | 6E-180 | PubMed |
| IL6ST protein levels | A | OR 1.07 | 7E-178 | PubMed |
Sources
- dbSNP: rs186021206 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies